Hot flashes and night sweats
Discuss the frequency, severity, and impact of temperature-related symptoms. Hormone therapy may help some eligible patients, but a provider must weigh possible benefits against individual risks.
WOMEN’S HORMONE HEALTH
Estradiol + Progesterone Cream
TOPICAL CREAM
A personalized, provider-guided compounded topical hormone treatment for eligible women experiencing symptoms associated with perimenopause, menopause, or other hormone changes.
Medication ships one month at a time.
All-inclusive pricing
Medication, if prescribed; Free expedited shipping; Shipped one month at a time; Ongoing provider support. A licensed provider reviews your information and determines whether treatment is medically appropriate. Treatment is not guaranteed.
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Prescription treatment requires an online medical evaluation. A licensed provider determines whether treatment is clinically appropriate. Treatment is not guaranteed.
PERSONALIZED WOMEN’S CARE
Care informed by your symptoms and history.
Menopause and other hormone changes can affect daily comfort, sleep, and well-being. Your experience is personal. A licensed provider reviews your concerns, health history, and goals before deciding whether a hormone treatment may be considered.
Treatment goals are individualized. A prescription is offered only when clinically appropriate, with ongoing review of potential benefits, risks, and your response. Individual results vary.
ABOUT THIS TREATMENT
What is compounded topical hormone therapy?
Estradiol is an estrogen, and progesterone is a different hormone. In this compounded topical treatment, both ingredients are prepared in a prescription cream for an individual patient. Your provider evaluates whether a compounded formulation is needed and how it fits your medical needs.
Both hormones may be prescribed together when clinically appropriate. For patients who have a uterus, estrogen treatment requires careful consideration of protection of the uterine lining. A compounded topical progesterone preparation should not be assumed to provide adequate endometrial protection; your provider must assess the specific formulation and whether another approach is more appropriate.
Compounded medications are prepared for an individual patient pursuant to a prescription and are not reviewed by the FDA for safety, effectiveness, or manufacturing quality in the same manner as FDA-approved products. This treatment is not identical to, or interchangeable with, an FDA-approved finished drug.
CONCERNS YOU MAY DISCUSS
A conversation about what matters to you.
Sleep and mood changes
Share sleep disruption and mood changes, including how they affect daily life. These concerns can have many causes, and hormone therapy may not be the appropriate treatment.
Vaginal and sexual wellness
Discuss dryness, discomfort, or changes in sexual wellness privately. Your provider can assess possible causes and whether this or a different treatment may be considered.
INDIVIDUALIZED PROVIDER REVIEW
Is treatment right for you?
Candidacy depends on more than symptoms alone. Your provider needs your personal and family medical history, menopause history, uterine status, current medications, and treatment goals to assess potential benefits and risks.
Use only as prescribed.
Follow the individual directions from your prescriber and dispensing pharmacy. Do not choose an application amount, area, or schedule based on someone else’s prescription. Ask your care team about handling precautions and avoiding unintended transfer to others.
Your provider determines follow-up and monitoring. Keep recommended screening appointments and communicate any new symptoms or changes in your health.
How it works
Three steps to personalized care.
Simple online care, reviewed by licensed medical providers.
- 01
Tell us about yourself
Complete a secure online health assessment so your provider can understand your goals, symptoms, and medical history.
- 02
Your provider reviews your care
A licensed medical provider evaluates your information and determines which treatment options may be clinically appropriate.
- 03
Begin your personalized plan
If prescribed, your treatment is delivered discreetly, with ongoing support and follow-up as needed.
WHAT’S INCLUDED
Support throughout your plan.
- Medication, if prescribed
- Free expedited shipping
- Shipped one month at a time
- Ongoing provider support
A licensed provider reviews your information and determines whether treatment is medically appropriate. Treatment is not guaranteed. Longer plans do not change the one-month-at-a-time shipping schedule.
Important Safety Information
- Tell your provider if you are pregnant, planning pregnancy, or breastfeeding. Hormone therapy is not intended for use during pregnancy; your provider must review breastfeeding and other individual considerations before prescribing.
- Disclose unexplained vaginal bleeding and any personal history or family history or risk of breast, uterine, or other estrogen-sensitive cancer. Tell your provider whether you have a uterus and about any prior gynecologic treatment or surgery.
- Disclose any history or risk of blood clots, stroke, heart attack, cardiovascular disease, or liver disease, as well as migraine history. Estrogen-containing therapy may increase the risk of serious blood clots and cardiovascular events and may not be appropriate for you.
- Share all prescriptions, over-the-counter medications, supplements, allergies, and other hormone treatments. Do not start, stop, or combine treatments without your provider’s guidance.
- Possible side effects may include skin irritation, breast tenderness, headache, nausea, and spotting or changes in vaginal bleeding. Contact your provider about new, persistent, or worsening symptoms, including new vaginal bleeding or a breast lump.
- Seek emergency medical care for chest pain, sudden shortness of breath, coughing blood, painful swelling in one leg, sudden severe headache, weakness on one side, difficulty speaking, sudden vision changes, or signs of a severe allergic reaction such as swelling of the face or throat or trouble breathing.
FREQUENTLY ASKED QUESTIONS
Questions about topical hormone care.
What is Estradiol + Progesterone Cream?
It is a compounded prescription topical formulation containing estradiol, an estrogen, and progesterone. It may be considered for eligible women experiencing menopause or hormone-change concerns after a licensed provider reviews their health history and treatment goals.
Why might both hormones be prescribed together?
Estrogen and progesterone have different roles. When estrogen therapy is considered for a patient who has a uterus, a provider must evaluate protection of the uterine lining. Do not assume that any compounded topical progesterone formulation provides adequate protection. Your provider determines whether this particular formulation and treatment plan are appropriate, or whether another option is needed.
Who may be eligible?
Eligibility depends on symptoms, age and menopause history, uterine status, personal and family medical history, medications, and individual risks. This treatment is not appropriate for everyone. Completing an assessment does not guarantee a prescription.
How do I use the cream?
Use it only as directed by your prescriber and dispensing pharmacy. Your provider determines your individual instructions. Do not change your treatment or share your medication with anyone else. Ask your provider about precautions to avoid unintended skin contact or transfer to others.
Is this compounded medication FDA-approved?
No. Compounded medications are prepared for an individual patient pursuant to a prescription and are not reviewed by the FDA for safety, effectiveness, or manufacturing quality in the same manner as FDA-approved products. This cream is not identical to, or interchangeable with, an FDA-approved finished drug. Discuss available options and the reason for compounding with your provider.
Will treatment relieve my symptoms?
Treatment may help some eligible patients, but no specific symptom improvement or timeline is guaranteed. Individual results vary. Your provider evaluates your response and may recommend a different approach based on symptoms, side effects, and ongoing review.
How are plans billed and shipped?
The 1 Month plan is $190/month, with $190 billed monthly. The 3 Months plan is $176.33/month, with $529 billed upfront. The 6 Months plan is $166.50/month, with $999 billed upfront. Medication, if prescribed, ships one month at a time; choosing a longer plan does not mean the entire term is shipped at once.
What is included?
Medication, if prescribed; Free expedited shipping; Shipped one month at a time; Ongoing provider support. A licensed provider reviews your information and determines whether treatment is medically appropriate. Treatment is not guaranteed.
What follow-up may be needed?
Your provider determines the appropriate follow-up and monitoring based on your history and treatment. Report new symptoms, bleeding changes, side effects, and medication changes promptly, and keep recommended screening and follow-up appointments.
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Begin with a private medical assessment.
Share your symptoms, medical history, and goals with a licensed provider. Treatment is not guaranteed.
Start Assessment